Michal Sharon | Mass Spectrometry | Best Researcher Award

Michal Sharon | Mass Spectrometry | Best Researcher Award

Prof. Michal Sharon , Weizmann Institute of Science ,Israel.

Prof. Michal Sharon ๐Ÿ‡ฎ๐Ÿ‡ฑ๐Ÿ‡ฉ๐Ÿ‡ช, born on March 25, 1972, is a distinguished scientist in biomolecular sciences at the Weizmann Institute of Science ๐Ÿงฌ. She holds Israeli and German citizenship and is a proud mother of three ๐Ÿ‘ฉโ€๐Ÿ‘งโ€๐Ÿ‘ฆ. Renowned for her groundbreaking work in mass spectrometry and structural biology, she has significantly advanced our understanding of large protein complexes ๐Ÿ”ฌ. Her career includes esteemed roles in academia and active leadership in promoting gender equality in science โ™€๏ธ๐Ÿ“š. She is the current President of AFIK and Head of the Dana and Yossie Hollander Center for Structural Proteomics ๐Ÿ›๏ธ.

Publication Profile

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Education & Experienceย 

๐ŸŽ“ Education
  • ๐Ÿ“ 1993โ€“1996: B.Sc. in Chemistry, The Hebrew University, Jerusalem, Cum laude

  • ๐Ÿ“ 1996โ€“2003: M.Sc./Ph.D. (Direct) in Structural Biology, Weizmann Institute of Science โ€“ Focus: NMR of protein complexes

  • ๐Ÿ“ 2003โ€“2006: Postdoc, University of Cambridge, UK โ€“ Focus: Mass spectrometry of non-covalent complexes

๐Ÿ’ผ Employment
  • ๐Ÿ‘ฉโ€๐Ÿ”ฌ 2006โ€“2007: Royal Society Research Fellow, University of Cambridge

  • ๐Ÿงช 2007โ€“2015: Senior Scientist (Assistant Prof.), Weizmann Institute of Science

  • ๐Ÿงฌ 2015โ€“2021: Associate Professor, Weizmann Institute of Science

  • ๐Ÿงซ 2021โ€“Present: Full Professor, Department of Biomolecular Sciences, Weizmann Institute

Suitability Summary

Prof. Michal Sharon, Full Professor at the Weizmann Institute of Science, is a globally recognized leader in structural proteomics and mass spectrometry, known for pioneering intact degradomics to study native protein complexes and proteasome function. Her highly cited researchโ€”including recent publications in PNAS (2025) and Journal of Extracellular Biology (2025)โ€”has uncovered critical insights into protein degradation, with far-reaching implications in biology and medicine. Trained at Cambridge and the Weizmann Institute, she combines deep expertise in NMR and native MS to push scientific boundaries. Alongside her research, Prof. Sharon serves as President of AFIK (Israeli Women Professors Forum) and leads multiple national and institutional efforts promoting gender equality in science. Her groundbreaking discoveries, academic leadership, and societal contributions make her an outstanding candidate for the Best Researcher Award.

Professional Developmentย 

Prof. Michal Sharon is a dynamic leader in academic and scientific circles ๐Ÿ’ผ๐Ÿ‘ฉโ€๐Ÿ”ฌ. She currently serves as the President of AFIK ๐Ÿ‘ฉโ€๐Ÿซ, the Israeli Women Professors Forum, and has been a prominent voice for gender equality in STEM fields โ™€๏ธ๐Ÿ”ฌ. Her involvement in various national committees, including GET and ESFRI, reflects her commitment to scientific excellence and diversity ๐ŸŒ๐ŸŒฑ. Through roles in promotion and review committees ๐Ÿ“, she has influenced scientific governance at the institutional and national levels. Her leadership of the Dana and Yossie Hollander Center for Structural Proteomics underscores her impact on infrastructure and research capacity building ๐Ÿงช๐Ÿ›๏ธ.

Research Focusย 

Prof. Sharon’s research lies at the intersection of structural biology and mass spectrometry ๐Ÿ”ฌ๐Ÿงฌ. She specializes in the analysis of large non-covalent protein complexes, providing crucial insights into cellular machinery at the molecular level ๐Ÿงซโš™๏ธ. Her work combines biochemical, biophysical, and computational techniques to unravel the dynamics and functions of protein assemblies in health and disease ๐Ÿง ๐Ÿฆ . This interdisciplinary approach has broad applications, ranging from drug design to understanding complex biological processes ๐Ÿ’Š๐Ÿ”. Her lab also pioneers developments in native mass spectrometry and structural proteomics, placing her at the forefront of biomolecular innovation ๐Ÿš€๐Ÿ“Š.

Awards and Honorsย 

  • ๐Ÿ† 2020โ€“Present: Head, Dana and Yossie Hollander Center for Structural Proteomics

  • ๐ŸŒŸ 2019โ€“Present: Elected Member, National Forum of Promoting Women Scientists

  • ๐Ÿงช 2019: Member, Israel Science Foundation (ISF) Review Committee

  • ๐Ÿ’ฌ 2019โ€“2021: Advisory Board Member, Journal of Analytical Chemistry

  • ๐Ÿงฉ 2018: Jury Member, Falling Walls Conference

  • ๐Ÿ‘ฉโ€๐Ÿ”ฌ 2023: Senior Scientists Appointment & Promotion Committee Member

  • ๐Ÿค 2022โ€“2024: Co-Head, National Active Forum for Gender Equality

Publication Top Notes

๐Ÿ“… 2025 | ๐Ÿ“„ Tracking proteasome degradation: A cross-organ analysis via intact degradomics mass spectrometry | ๐Ÿ”ฌ PNAS | ๐Ÿ”— DOI: 10.1073/pnas.2419607122 | ๐Ÿ” Cited by: TBD

๐Ÿ“… 2025 | ๐Ÿ“„ Molecular insights into the unique properties of the bloodโ€circulating proteasome | ๐Ÿ”ฌ Journal of Extracellular Biology | ๐Ÿ”— DOI: 10.1002/jex2.70034 | ๐Ÿ” Cited by: TBD

๐Ÿ“… 2024 | ๐Ÿ“„ Systematic identification of 20S proteasome substrates | ๐Ÿ”ฌ Molecular Systems Biology | ๐Ÿ”— DOI: 10.1038/s44320-024-00015-y | ๐Ÿ” Cited by: TBD

๐Ÿ“… 2023 | ๐Ÿ“„ The C-terminal tail of CSNAP attenuates the CSN complex | ๐Ÿ”ฌ Life Science Alliance | ๐Ÿ”— DOI: 10.26508/lsa.202201634 | ๐Ÿ” Cited by: TBD

๐Ÿ“… 2022 | ๐Ÿ“„ Influence of Asp Isomerization on Trypsin and Trypsin-like Proteolysis | ๐Ÿ”ฌ Analytical Chemistry | ๐Ÿ”— DOI: 10.1021/acs.analchem.2c02585 | ๐Ÿ” Cited by: TBD

๐Ÿ“… 2022 | ๐Ÿ“„ The C-terminal tail of CSNAP attenuates the CSN complex | ๐Ÿงช Preprint | ๐Ÿ”— DOI: 10.1101/2022.07.18.500399 | ๐Ÿ” Cited by: TBD

๐Ÿ“… 2022 | ๐Ÿ“„ Characterizing Endogenous Protein Complexes with Biological Mass Spectrometry | ๐Ÿ”ฌ Chemical Reviews | ๐Ÿ”— DOI: 10.1021/acs.chemrev.1c00217 | ๐Ÿ” Cited by: TBD