Prof. Michal Sharon , Weizmann Institute of Science ,Israel.
Prof. Michal Sharon 🇮🇱🇩🇪, born on March 25, 1972, is a distinguished scientist in biomolecular sciences at the Weizmann Institute of Science 🧬. She holds Israeli and German citizenship and is a proud mother of three 👩👧👦. Renowned for her groundbreaking work in mass spectrometry and structural biology, she has significantly advanced our understanding of large protein complexes 🔬. Her career includes esteemed roles in academia and active leadership in promoting gender equality in science ♀️📚. She is the current President of AFIK and Head of the Dana and Yossie Hollander Center for Structural Proteomics 🏛️.
Publication Profile
Education & Experience
🎓 Education
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📍 1993–1996: B.Sc. in Chemistry, The Hebrew University, Jerusalem, Cum laude
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📍 1996–2003: M.Sc./Ph.D. (Direct) in Structural Biology, Weizmann Institute of Science – Focus: NMR of protein complexes
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📍 2003–2006: Postdoc, University of Cambridge, UK – Focus: Mass spectrometry of non-covalent complexes
💼 Employment
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👩🔬 2006–2007: Royal Society Research Fellow, University of Cambridge
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🧪 2007–2015: Senior Scientist (Assistant Prof.), Weizmann Institute of Science
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🧬 2015–2021: Associate Professor, Weizmann Institute of Science
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🧫 2021–Present: Full Professor, Department of Biomolecular Sciences, Weizmann Institute
Suitability Summary
Prof. Michal Sharon, Full Professor at the Weizmann Institute of Science, is a globally recognized leader in structural proteomics and mass spectrometry, known for pioneering intact degradomics to study native protein complexes and proteasome function. Her highly cited research—including recent publications in PNAS (2025) and Journal of Extracellular Biology (2025)—has uncovered critical insights into protein degradation, with far-reaching implications in biology and medicine. Trained at Cambridge and the Weizmann Institute, she combines deep expertise in NMR and native MS to push scientific boundaries. Alongside her research, Prof. Sharon serves as President of AFIK (Israeli Women Professors Forum) and leads multiple national and institutional efforts promoting gender equality in science. Her groundbreaking discoveries, academic leadership, and societal contributions make her an outstanding candidate for the Best Researcher Award.
Professional Development
Prof. Michal Sharon is a dynamic leader in academic and scientific circles 💼👩🔬. She currently serves as the President of AFIK 👩🏫, the Israeli Women Professors Forum, and has been a prominent voice for gender equality in STEM fields ♀️🔬. Her involvement in various national committees, including GET and ESFRI, reflects her commitment to scientific excellence and diversity 🌍🌱. Through roles in promotion and review committees 📝, she has influenced scientific governance at the institutional and national levels. Her leadership of the Dana and Yossie Hollander Center for Structural Proteomics underscores her impact on infrastructure and research capacity building 🧪🏛️.
Research Focus
Prof. Sharon’s research lies at the intersection of structural biology and mass spectrometry 🔬🧬. She specializes in the analysis of large non-covalent protein complexes, providing crucial insights into cellular machinery at the molecular level 🧫⚙️. Her work combines biochemical, biophysical, and computational techniques to unravel the dynamics and functions of protein assemblies in health and disease 🧠🦠. This interdisciplinary approach has broad applications, ranging from drug design to understanding complex biological processes 💊🔍. Her lab also pioneers developments in native mass spectrometry and structural proteomics, placing her at the forefront of biomolecular innovation 🚀📊.
Awards and Honors
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🏆 2020–Present: Head, Dana and Yossie Hollander Center for Structural Proteomics
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🌟 2019–Present: Elected Member, National Forum of Promoting Women Scientists
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🧪 2019: Member, Israel Science Foundation (ISF) Review Committee
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💬 2019–2021: Advisory Board Member, Journal of Analytical Chemistry
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🧩 2018: Jury Member, Falling Walls Conference
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👩🔬 2023: Senior Scientists Appointment & Promotion Committee Member
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🤝 2022–2024: Co-Head, National Active Forum for Gender Equality
Publication Top Notes
📅 2025 | 📄 Tracking proteasome degradation: A cross-organ analysis via intact degradomics mass spectrometry | 🔬 PNAS | 🔗 DOI: 10.1073/pnas.2419607122 | 🔁 Cited by: TBD
📅 2025 | 📄 Molecular insights into the unique properties of the blood‐circulating proteasome | 🔬 Journal of Extracellular Biology | 🔗 DOI: 10.1002/jex2.70034 | 🔁 Cited by: TBD
📅 2024 | 📄 Systematic identification of 20S proteasome substrates | 🔬 Molecular Systems Biology | 🔗 DOI: 10.1038/s44320-024-00015-y | 🔁 Cited by: TBD
📅 2023 | 📄 The C-terminal tail of CSNAP attenuates the CSN complex | 🔬 Life Science Alliance | 🔗 DOI: 10.26508/lsa.202201634 | 🔁 Cited by: TBD
📅 2022 | 📄 Influence of Asp Isomerization on Trypsin and Trypsin-like Proteolysis | 🔬 Analytical Chemistry | 🔗 DOI: 10.1021/acs.analchem.2c02585 | 🔁 Cited by: TBD
📅 2022 | 📄 The C-terminal tail of CSNAP attenuates the CSN complex | 🧪 Preprint | 🔗 DOI: 10.1101/2022.07.18.500399 | 🔁 Cited by: TBD
📅 2022 | 📄 Characterizing Endogenous Protein Complexes with Biological Mass Spectrometry | 🔬 Chemical Reviews | 🔗 DOI: 10.1021/acs.chemrev.1c00217 | 🔁 Cited by: TBD